Two people died following a crash that closed a road for more than 16 hours, police said.
The incident happened on the A43 in Northamptonshire between the Holcot/Sywell Roundabout, and the Walgrave/Hannington junction, on Monday at about 15:40 BST.
Police, fire and ambulance crews were called after a white Citroen Belingo van and a white Scania goods vehicle travelling in opposite directions crashed.
Northamptonshire Police confirmed the driver of the Citroen, a man in his 40s, and his passenger, a man in his 30s, died at the scene.
A second passenger of the Citroen, a man in his 20s, sustained serious injuries.
After the first crash, a second collision then occurred between the drivers of the Scania and a blue Mercedes AMG but both drivers were uninjured.
The road was opened on Tuesday morning and officers are appealing for information.
